The antimicrobial activity of the roots of Alangium salviifoliium L. studied against bacteria, Bacillus subtilis, Escherichia coli, Klebsiella pneumoniae, Pseudomonas aeruginosa, Proteus vulgaris, Staphylococcus aureus, Streptomyces pneumoniae and fungi Aspergillus niger, Candida albicans and Saccharomyces cerevisiae by the agar well diffusion method. Antimicrobial activity was recorded in the order of hexane, chloroform, methanol, ethanol and water extracts. Three concentrations (50, 75 and 100 mg/ml) of each extracts were studied in the antimicrobial activity which involved the determination of inhibition zone values. As the extract dosage level increases the inhibitory effect also increased. All the extracts have showed antimicrobial activity against all tested bacteria and fungi. Ethanol extract has exhibited the highest antimicrobial activity against Proteus vulgaris followed by Candida albicans and Saccharomyces cerevisiae, while methanol extract exhibited the highest activity against Streptomycis pneumoniae. The antimicrobial activity of the extracts was compared to the standard antibiotics, Tetracycline and Clotrimazole. The minimum inhibitory concentration of the chloroform, methanol, ethanol and water extracts were determined by the agar dilution method ranged between 10- 1000 µg/ml and 10 µg/ml with that of Proteus vulgaris being the least phytochemical screening of the plant revealed the presence of tannins, alkaloids, flavonoids and saponins. The results of this study support the traditional use of Alangium salviifoliium L. root as an antimicrobial agent.
Plant based antimicrobials represent a vast untapped source for medicines and further exploration of plant antimicrobials need to occur. Antimicrobials of plant origin have enormous therapeutic potential (1). Human infections particularly those involving microorganisms i.e. bacteria, fungi, viruses. They cause serious infections in tropical and subtropical countries of the world. In recent years, multiple drug resistance in human pathogenic microorganisms has been developed due to indiscriminate use of commercial antimicrobial drugs commonly used in the treatment of such diseases (2,3)
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