Volume 1, Issue 1

Docking studies of doxycycline on pathogenic Leptospira Species with common pharmacopore

Author

K. Sandeep Solmon*, G.Suneetha, P.Kiranmayi and I. Bhaskar Reddy

Abstract

A B S T R A C T

Every disease can be cured if its roots are traced; means there is cure for every disease. Leptospirosis is a hidden and emerging public health problem as it causes fever, acute renal failure and jaundice. The major outer membrane lipoprotein “LipL32” is expressed during infection which is highly conserved among pathogenic leptospira. It is absent in non-pathogenic avirulent leptospira. Insilico comparison of amino acid sequences of LipL32 showed 97.8% average sequence identity among the pathogenic species. In this study some 3D model were built for LipL32 protein using molecular modelling. Protein hydrophobicity plots were utilized to locate the antigenic sites. Docking studies of retrieved structures and modeled LipL32 proteins with doxycycline revealed that doxycycline can inhibit LipL32 proteins of Leptospira santarosai, Leptospira weilii and Leptospira kirschner as they have bound docking with doxycycline. They share a common pharmacopore within a genus and a common drug may be utilized to combat all the related species.

 

DOI

https://doi.org/10.62226/ijarst20120122

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