Volume 11, Issue 1

Evaluation of neuroprotective activity of Caesalpinia sappan Linn. against Aluminum chloride induced neurotoxicity in rats

Author

Mohammed Zubair A S. 1 , S. Babitha2 , Pooja R C3 , M S Naveeda Khanum4 , Rekha Y V5

Abstract

Objective: The present study was designed to evaluate the neuroprotective activity of hydroalcoholic extract of Caesalpinia sappan Linn. (HAECS) against aluminum chloride (AlCl3) induced neurotoxicity in rats. Materials and methods: The neuroprotective activity of HAECS was assessed by using AlCl3 induced neurotoxicity models in rats. In this study, neurotoxicity was induced by the administration of AlCl3 (100 mg/kg, p.o.) for 42 days. In this model both the test doses of HAECS (200 and 400mg/kg) were administered 1 hour after AlCl3 administration. The reference standard was Donepezil hydrochloride (1mg/kg p.o.). The degree of protection was assessed by various behavioral, antioxidant parameters and Acetylcholinesterase (AChE) estimation. Further, neuronal damage was assessed by brain histopathological observations. Results: Treatment with HAECS significantly attenuated AlCl3 alteration in behavioral and physiological responses. It prevented the elevation of AchE and LPO. An increase in GSH, SOD, and CAT was observed in groups treated with HAECS and it also reduced the histopathological changes induced by AlCl3 administration. Conclusion: The present study suggests that the hydroalcoholic extract of Caesalpinia sappan Linn. possesses significant neuroprotective activity against AlCl3 induced neurotoxicity in rats. The observed effect could be possibly attributed to its potential antioxidant activity and anti-inflammatory property due to the presence of various neuroprotective constituents

DOI

https://doi.org/10.62226/ijarst20220152

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