Volume 13, Issue 2

Preparation and Study of Stability Pharmaceutical Composition [PSMA-11] and Radiopharmaceutical [99mtc]-PSMA-11 Labeled With 99mtc Radionuclide

Author

*Usarov Z.O1 ., Khujaev S2 ., Abdukayumov A.M1 ., Rikhsiev A.Z1 ., Hajiev L.O1 .

Abstract

This work is devoted to the study of the synthesis of a pharmaceutical composition (PhC) [PSMA-11] in the form of a lyophilisate with optimization of the amount of ingredients and sodium pertechnetate (Na99mTcO4) from the 99mTc Generator to obtain the radiopharmaceutical [ 99mTc]-PSMA-11 with the highest possible radiochemical yield (RCY) and radiochemical purity (RCP). The stability of radiopharmaceutical [99mТс]- PSMA-11 in 0.9% NaCl solution and in human serum was determined. The preliminary shelf life of PhC [PSMA-11] was determined and set to 6 months.

DOI

https://doi.org/10.62226/ijarst20241318

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*Usarov Z.O1 ., Khujaev S2 ., Abdukayumov A.M1 ., Rikhsiev A.Z1 ., Hajiev L.O1 . | Preparation and Study of Stability Pharmaceutical Composition [PSMA-11] and Radiopharmaceutical [99mtc]-PSMA-11 Labeled With 99mtc Radionuclide | DOI : https://doi.org/10.62226/ijarst20241318

Journal Frequency: ISSN 2320-1126, Monthly
Paper Submission: Throughout the month
Acceptance Notification: Within 6 days
Subject Areas: Engineering, Science & Technology
Publishing Model: Open Access
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Publication Impact Factor: 6.76
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